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Event Description

This webinar is aimed at informing end-users involved in pre-clinical drug screening (discovery and development) of the models and techniques available to elucidate the causes and consequences of gastrointestinal (GI) toxicities and pathologies. This information will ultimately help users design dose schedules and formulations that can minimise such effects, or quickly identify test articles that have a high likelihood of toxicity in vivo or in the clinic. Dr. Booth has been a key opinion leader is this field for 25 years, working with many different biotechnology and pharmaceutical companies to design and perform studies that address their pertinent questions. This webinar will review some of the models in use and discuss current practice when running pre-clinical studies for sponsors at Epistem. Specifically, there will be an overview of:

  • The implications of the timings of observed toxicity
  • The consequences of interrupted cell production or cell death in various tissue populations
  • The techniques available to measure perturbed barrier function
  • Predictive in vitro screening techniques to identify articles likely to cause in vivo toxicity


Historical data will be presented to illustrate the techniques and responses to known therapeutics, along with typical study designs and readouts.

The aim of this webinar is to enable the end-user to select the best model and study design to predict or assess GI toxicity.

There may be many networking opportunities at the Pre-clinical Models of Intestinal Toxicity. Find out more in the event details below.

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Event Details

Conference/Event Dates: 06/10/2016 - 06/10/2016
Classification: Consumer
Primary Industry: Clinical Pharmacology
Other Industries: Business, Clinical Pharmacology, Gastroenterology, Pharmaceutical, Professional Healthcare, Sciences
Audience: Chief Scientific Officers (CSO), Senior Executives, Directors, Team Leaders and Senior Scientists involved in understanding, predicting or controlling off-target or on-target/off-tissue toxicity to the intestinal epithelium.

Relevant job areas or roles:

Pre-clinical Development
Pre-clinical Pharmacology
Pre-clinical Research
Pre-clinical Drug Development
Discovery Scientists
Pharmaceutical Toxicologists

Booth Details

Booth Size Booth Cost   Available Amenities
No exhibiting.   Electricity: n/a
  Water: n/a
  Generator: n/a
  Marketing Vehicles Allowed: n/a
Other Booth Sizes Available: n/a

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Pre-clinical Models of Intestinal Toxicity

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