This meeting is co-hosted by the National Congress of American Indians, the National Human Genome Research Institute, and the National Museum of the American Indian as part of the Genome: Unlocking Life’s Code exhibit at the Smithsonian’s National Museum of Natural History. Our goal in hosting this Symposium is to demonstrate the range of perspectives in Native communities on genomics, highlight key topics for ongoing community conversation, and create a video recording of the conversations that can be shared with Native communities as they host similar conversations across Indian Country. We plan to feature four panels of speakers—including Dr. Ron Whitener (University of Washington), Dr. Nanibaa’ Garrison (Vanderbilt University), Dr. Sarah Anzick (NIH/Rocky Mountain Laboratories), Dr. Rosita Worl (Sealaska Heritage Institute), Valerie Segrest (Northwest Indian College), and Dr. Francine Gachupin (University of Arizona). Panels include: Can genetics improve Native health?; The ethics of blood; Genomics & ancestry: Ethics, origins, and policy; and Insights from the field: Next generation Native researchers.